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Science. 2006 Nov 10;314(5801):982-5. PubMed; doi 10.1126/science.1133276

Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH.

Kazantseva, A.; Goltsov, A.; Zinchenko, R.; Grigorenko, A. P.; Abrukova, A. V.; Moliaka, Y. K.; Kirillov, A. G.; Guo, Z.; Lyle, S.; Ginter, E. K.; Rogaev, E. I.

The molecular mechanisms controlling human hair growth and scalp hair loss are poorly understood. By screening about 350,000 individuals in two populations from the Volga-Ural region of Russia, we identified a gene mutation in families who show an inherited form of hair loss and a hair growth defect. Affected individuals were homozygous for a deletion in the LIPH gene on chromosome 3q27, caused by short interspersed nuclear element-retrotransposon-mediated recombination. The LIPH gene is expressed in hair follicles and encodes a phospholipase called lipase H (alternatively known as membrane-associated phosphatidic acid-selective phospholipase A1alpha), an enzyme that regulates the production of bioactive lipids. These results suggest that lipase H participates in hair growth and development.



 


  Московский Государственный Университет имени М.В.Ломоносова



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